Transplantation of live cells as therapeutic agents is poised to offer new treatment options for
a wide range of acute and chronic diseases. However, the biological complexity of cells has …

The optimization of pharmaceutical bioprocesses suffers from several challenges like
complexity, upscaling costs, regulatory approval, leading to the risk of delivering …

For practical use of pluripotent stem cells (PSCs) for disease modelling, drug screening, and
regenerative medicine, the cell differentiation process needs to be properly refined to …

Abstract Objectives Guided Tissue Regeneration (GTR) is a popular clinical procedure for
periodontal tissue regeneration. However, its key component, the barrier membrane, is …

Exciting developments in the cell therapy field over the last decades have led to an
increasing number of clinical trials and the first cell products receiving marketing …

The cell therapy industry is rapidly growing with several new products approved for clinical
use over the past few years and many more currently in clinical trials. Nonetheless, a …

This case study describes the application of Quality by Design elements to the process of
culturing Chinese hamster ovary cells in the production of a monoclonal antibody. All steps …

Abstract “To consult the statistician after an experiment is finished is often merely to ask him
to conduct a post mortem examination. He can perhaps say what the experiment died of.” …

Stem cells, including mesenchymal stem cells and pluripotent stem cells, are becoming an
indispensable tool for various biomedical applications including drug discovery, disease …

The application of human induced pluripotent stem cells (hiPSCs) provides tremendous
opportunities in cell therapy. However, culturing these cells faces many practical challenges …