Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Metabolic syndrome is a global public health problem and predisposes individuals to
obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain …

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation
of specific T-cell responses and for the development of immune tolerance. Immature DCs …

Perivascular adipose tissue (PVAT), the adipose tissue that surrounds most of the
vasculature, has emerged as an active component of the blood vessel wall regulating …

Adipose tissue is an immunologically active organ that controls host physiology, partly
through the release of mediators termed adipokines. In obesity, adipocytes and infiltrating …

Chemerin, a chemoattractant protein and adipokine, has been identified as the endogenous
ligand for a G protein–coupled receptor encoded by the gene CMKLR1 (also known as …

Chemerin is a small chemotactic protein originally identified as the natural ligand of
CMKLR1. More recently, two other receptors, GPR1 and CCRL2, have been reported to bind …

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Chemerin is an adipokine secreted by adipocytes and associated with obesity, insulin
resistance and metabolic syndrome. Different chemerin fragments with pro-or anti …

ChemR23 is a G protein–coupled receptor that is triggered by two ligands, the peptide
chemerin and the eicosapentaenoic acid–derived lipid mediator resolvin E1 (RvE1) …