Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Nanotherapeutics exhibit unique advantages in clinical outcomes compared with
conventional small molecular drugs. The past three decades have seen intensive research …

Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

During the past few decades, polymeric micelles have raised special attention as novel
nano-sized drug delivery systems for optimizing the treatment and diagnosis of numerous …

Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

All drugs for cancer therapy face several transportation barriers on their tortuous journey to
the action sites. To overcome these barriers, an effective drug delivery system for cancer …

Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …

This review focuses on the smart chemistry that has been utilized in developing polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

Highlights•Doxorubicin (DOX) is considered one of the most effective chemotherapeutic
agents.•Dose-cumulative cardiotoxicity is the most dangerous adverse effect.•DOX-based …