Synergy and antagonism in natural product extracts: when 1+ 1 does not equal 2
Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …
and Prevention, approximately 18% of the US population uses natural products (including …
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
The molecular mechanism of action of artemisinin—the debate continues
PM O'Neill, VE Barton, SA Ward - Molecules, 2010 - mdpi.com
Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
DA Fidock, T Nomura, AK Talley, RA Cooper… - Molecular cell, 2000 - cell.com
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …
Artemisinins target the SERCA of Plasmodium falciparum
U Eckstein-Ludwig, RJ Webb, IDA Van Goethem… - Nature, 2003 - nature.com
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent
antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum …
antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum …
Artemisinin: mechanisms of action, resistance and toxicity
SR Meshnick - International journal for parasitology, 2002 - Elsevier
Artemisinin and its derivatives are widely used throughout the world. The mechanism of
action of these compounds appears to involve the heme-mediated decomposition of the …
action of these compounds appears to involve the heme-mediated decomposition of the …
Discovery, mechanisms of action and combination therapy of artemisinin
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
especially in Africa. Throughout history, antimalarial medicines have been one of the most …
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
HM Ismail, V Barton, M Phanchana… - Proceedings of the …, 2016 - National Acad Sciences
The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …
Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites
F Rocamora, L Zhu, KY Liong, A Dondorp… - PLoS …, 2018 - journals.plos.org
Due to their remarkable parasitocidal activity, artemisinins represent the key components of
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …
first-line therapies against Plasmodium falciparum malaria. However, the decline in efficacy …