BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

This review addresses current understanding of the germline stem cell niche unit in
mammalian testes. Spermatogenesis is a classic model of tissue-specific stem cell function …

Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Spermatogonial stem cells (SSCs) can produce numerous male gametes after
transplantation into recipient testes, presenting a valuable approach for gene therapy and …

Advanced paternal age has been associated with an increased risk for spontaneous
congenital disorders and common complex diseases (such as some cancers, schizophrenia …

Spermatogenesis is a dynamic developmental process that includes stem cell proliferation
and differentiation, meiotic cell divisions and extreme chromatin condensation. Although …

Spermatogenesis is a complex process by which spermatogonial stem cells (SSCs) self-
renew and differentiate into spermatozoa under the elaborate coordination of testicular …

Results. Two and a half weeks after initiation of the testicular cell culture, the first germline
stem cell (GSC) clusters appeared. Testicular cells were cultured for 20 and 15.5 weeks from …

Gamete failure-derived infertility affects millions of people worldwide; for many patients,
gamete donation by unrelated donors is the only available treatment. Embryonic stem cells …