Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Introduction Metaproteomics is a rapidly advancing field that offers unique insights into the
taxonomic composition and the functional activity of microbial communities, and their effects …

Peripheral nerve damage initiates a complex series of structural and cellular processes that
culminate in chronic neuropathic pain. The recent success of a type 2 angiotensin II (Ang II) …

The relatively high efficacy of opioids, which have associated risks of addiction, tolerance,
and dependence, for the management of acute and terminal pain has been a major driver of …

Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …

Neuropathic pain remains poorly managed by current therapies, highlighting the need to
improve our knowledge of chronic pain mechanisms. In neuropathic pain models, dorsal …