The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

Abstract Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional
elongation, is a promising target for cancer therapy, particularly for cancers driven by …

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that
exhibits extremely high levels of genetic complexity and yet a relatively uniform …

Summary Cyclin-dependent kinase 7 (CDK7) is a central regulator of the cell cycle and gene
transcription. However, little is known about its impact on genomic instability and cancer …

The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …

The transition between transcriptional initiation and elongation by RNA polymerase (Pol) II is
associated with phosphorylation of its C-terminal tail (CTD). Depletion of Kin28, the TFIIH …

The Mediator complex allows communication between transcription factors and RNA
polymerase II (RNAPII). Cyclin-dependent kinase 8 (CDK8), the kinase found in some …

The function of human TFIIH-associated Cdk7 in RNA polymerase II (Pol II) transcription and
C-terminal domain (CTD) phosphorylation was investigated in analogue-sensitive Cdk7 …

Summary Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but
its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which …