Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM),
which provide cells with structural support and mechanical cues that influence diverse …

Epithelial cells have an ability termed 'cell competition', which is an immune surveillance-like
function that extrudes precancerous cells from the epithelial layer, leading to apoptosis and …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Our understanding of cancer and the key pathways that drive cancer survival has expanded
rapidly over the past several decades. However, there are still important challenges that …

The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-
function (GOF) activities that affect molecular pathways crucial for tumorigenesis and …

After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among
women, worldwide. Although advances in screening approaches and targeted therapeutic …

AMP-activated protein kinase (AMPK) functions as an energy sensor and is pivotal in
maintaining cellular metabolic homeostasis. Numerous studies have shown that down …

In order to gain a greater understanding of the factors that drive spatial organization in
multicellular aggregates of cancer cells, we investigate the segregation patterns of 6 breast …