Advances in microfluidic technologies in organoid research
Organoids have emerged as major technological breakthroughs and novel organ models
that have revolutionized biomedical research by recapitulating the key structural and …
that have revolutionized biomedical research by recapitulating the key structural and …
Liver organoids: a promising three-dimensional model for insights and innovations in tumor progression and precision medicine of liver cancer
Y Chen, Y Liu, S Chen, L Zhang, J Rao, X Lu… - Frontiers in …, 2023 - frontiersin.org
Primary liver cancer (PLC) is one type of cancer with high incidence rate and high mortality
rate in the worldwide. Systemic therapy is the major treatment for PLC, including surgical …
rate in the worldwide. Systemic therapy is the major treatment for PLC, including surgical …
[HTML][HTML] Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening
H Fang, H Xu, J Yu, H Cao, L Li - Biomolecules, 2024 - mdpi.com
Many drug and therapeutic modalities have emerged over the past few years. However,
successful commercialization is dependent on their safety and efficacy evaluations. Several …
successful commercialization is dependent on their safety and efficacy evaluations. Several …
Uniform sized cancer spheroids production using hydrogel-based droplet microfluidics: a review
Abstract Three-dimensional (3D) cell culture models have been extensively utilized in
various mechanistic studies as well as for drug development studies as superior in vitro …
various mechanistic studies as well as for drug development studies as superior in vitro …
[HTML][HTML] Tumor organoids for primary liver cancers: A systematic review of current applications in diagnostics, disease modeling, and drug screening
AA Qureshi, CJ Wehrle, S Ferreira-Gonzalez, C Jiao… - JHEP Reports, 2024 - Elsevier
Background & Aims Liver cancer-related deaths are projected to exceed one million
annually by 2030. Existing therapies have significant limitations, including severe side …
annually by 2030. Existing therapies have significant limitations, including severe side …
Patient-derived organoid models to decode liver pathophysiology
BJ Dwyer, JEE Tirnitz-Parker - Trends in Endocrinology & Metabolism, 2024 - cell.com
Liver diseases represent a growing global health challenge, and the increasing prevalence
of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving …
of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving …
Toward reproducible tumor organoid culture: focusing on primary liver cancer
L Guo, C Li, W Gong - Frontiers in Immunology, 2024 - frontiersin.org
Organoids present substantial potential for pushing forward preclinical research and
personalized medicine by accurately recapitulating tissue and tumor heterogeneity in vitro …
personalized medicine by accurately recapitulating tissue and tumor heterogeneity in vitro …