[HTML][HTML] Persister cancer cells: Iron addiction and vulnerability to ferroptosis
R Rodriguez, SL Schreiber, M Conrad - Molecular cell, 2022 - cell.com
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained
occurrence of peroxidized phospholipids, which are subject to iron-mediated production of …
occurrence of peroxidized phospholipids, which are subject to iron-mediated production of …
Nanostructured particles assembled from natural building blocks for advanced therapies
Advanced treatments based on immune system manipulation, gene transcription and
regulation, specific organ and cell targeting, and/or photon energy conversion have …
regulation, specific organ and cell targeting, and/or photon energy conversion have …
Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
X Wang, Y Chen, X Wang, H Tian, Y Wang, J Jin… - Cancer research, 2021 - AACR
Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction.
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …
Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment …
The hallmarks of ferroptosis
SJ Dixon, BR Stockwell - Annual review of cancer biology, 2019 - annualreviews.org
Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define …
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define …
[HTML][HTML] Glioblastoma stem cells: driving resilience through chaos
BC Prager, S Bhargava, V Mahadev, CG Hubert… - Trends in cancer, 2020 - cell.com
Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …
[HTML][HTML] m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program
The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
Ferroptosis: mechanisms and implications for cancer development and therapy response
As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …
[HTML][HTML] Recent advances in drug delivery systems for targeting cancer stem cells
H Duan, Y Liu, Z Gao, W Huang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …
The roles of NRF2 in modulating cellular iron homeostasis
MJ Kerins, A Ooi - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …
Iron metabolism: pathophysiology and pharmacology
K Roemhild, F von Maltzahn, R Weiskirchen… - Trends in …, 2021 - cell.com
Iron is essential in many physiological processes, including DNA metabolism, oxygen
transport, and cellular energy generation. Deregulated iron metabolism, which results in iron …
transport, and cellular energy generation. Deregulated iron metabolism, which results in iron …