Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Transforming growth factor–β1 (TGF-β1) is inextricably linked to regulatory T cell (Treg)
biology. However, precisely untangling the role for TGF-β1 in Treg differentiation and …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …

Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory
mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was …

Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …

Visceral adipose tissue (VAT) is an energy store and endocrine organ critical for metabolic
homeostasis. Regulatory T (Treg) cells restrain inflammation to preserve VAT homeostasis …

Maintenance of tissue homeostasis is dependent on the communication between stem cells
and supporting cells in the same niche. Regulatory T cells (Treg cells) are emerging as a …

The tissues are the site of many important immunological reactions, yet how the immune
system is controlled at these sites remains opaque. Recent studies have identified Foxp3+ …