In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Protein phosphorylation is a critical mechanism that biology uses to govern cellular
processes. To study the impact of phosphorylation on protein properties, a fully and …

Therapeutic strategies targeting nuclear receptors (NRs) beyond their endogenous ligand
binding pocket have gained significant scientific interest driven by a need to circumvent …

Dissociation between the healthy and toxic effects of cortisol, a major stress‐responding
hormone has been a widely used strategy to develop anti‐inflammatory glucocorticoids with …

Over the past two decades, molecular glues (MGs) have gradually attracted the attention of
the pharmaceutical community with the advent of MG degraders such as IMiDs and …

Background High blood glucose level is one of the main characteristics of diabetes mellitus.
Based on previous studies, it is speculated longevity families may have certain advantages …

S100 proteins are small, dimeric, Ca2+-binding proteins of considerable interest due to their
associations with cancer and rheumatic and neurodegenerative diseases. They control the …

The ubiquitously expressed glucocorticoid receptor (GR) is a nuclear receptor that controls a
broad range of biological processes and is activated by steroidal glucocorticoids such as …

Primary generalized glucocorticoid resistance syndrome is a rare genetic disorder
characterized by resistance of entire tissues to glucocorticoids. Affected subjects …