CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …

Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

Cell therapies such as tumor-infiltrating lymphocyte (TIL) therapy have shown promise in the
treatment of patients with refractory solid tumors, with improvement in response rates and …

The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the
migration, adhesion, and activation of T cells through interactions with intercellular adhesion …

With the rapid development of nanotechnology, the potential adverse health effects of
nanoparticles have been caught more attention and become global concerns. However, the …

T cells are fundamental components in tumour immunity and cancer immunotherapies,
which have made immense strides and revolutionized cancer treatment paradigm. However …

Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been
systematically studied whether there are regulators that uniquely or broadly contribute to T …

Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of
research and yielded significant fundamental insights into the regulation of immune …

Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger
harmful inflammation and immune-related disorders. T follicular helper (Tfh) cells, central to …

Follicular T helper (Tfh) cells are a subset of CD4+ T cells that play an important role in the
formation of germinal centers and the maturation and differentiation of affinity‐matured B …