Osteoporosis has been defined as the silent disease of the 21st century, becoming a public
health risk due to its severity, chronicity and progression and affecting mainly …

Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease
and a definite risk factor for many other diseases. Homocysteine is biosynthesized from …

Background Whether a modestly elevated homocysteine level is causally associated with an
increased risk of cardiovascular disease remains unestablished. We conducted a Mendelian …

This text is intended for those who wish to understand the complex relationships between
diet and risks of important diseases, such as cancer and cardiovascular disease. It is aimed …

Associations between modifiable exposures and disease seen in observational
epidemiology are sometimes confounded and thus misleading, despite our best efforts to …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Objective: To assess whether the association of serum homocysteine concentration with
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is …

Objective In the absence of head-to-head randomized trials, indirect comparisons of
treatments across separate trials can be performed. However, these analyses may be …