Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

A practical guide to the construction of radiometallated bioconjugates for positron emission tomography

BM Zeglis, JS Lewis - Dalton Transactions, 2011 - pubs.rsc.org
Positron emission tomography (PET) has become a vital imaging modality in the diagnosis
and treatment of disease, most notably cancer. A wide array of small molecule PET …

The renaissance of the 68Ge/68Ga radionuclide generator initiates new developments in 68Ga radiopharmaceutical chemistry

F Roesch, PJ Riss - Current topics in medicinal chemistry, 2010 - ingentaconnect.com
68Ge/68Ga radionuclide generators have been investigated for almost fifty years now, since
the cyclotronindependent availability of positron emitting 68Ga via the 68Ge/68Ga system …

Tailoring the Recognition Property of a 19F-Labeled Gallium-Based NMR Probe: The Influence of the Metal Center

J Liang, Z Xu, J Wu, Y Zhao - Analytical Chemistry, 2023 - ACS Publications
Chirality is a fundamental property of nature and an essential element of the life process. As
the biological activities, metabolic pathways, and toxicity of individual enantiomers are often …

Modern developments in bifunctional chelator design for gallium radiopharmaceuticals

PRWJ Davey, BM Paterson - Molecules, 2022 - mdpi.com
The positron-emitting radionuclide gallium-68 has become increasingly utilised in both
preclinical and clinical settings with positron emission tomography (PET). The synthesis of …

Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals

BM Zeglis, JL Houghton, MJ Evans… - Inorganic …, 2014 - ACS Publications
Over the past several decades, radionuclides have matured from largely esoteric and
experimental technologies to indispensible components of medical diagnostics. Driving this …

Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions

V Carroll, DW Demoin, TJ Hoffman, SS Jurisson - Radiochimica acta, 2012 - degruyter.com
Radiometals play an important role in diagnostic and therapeutic radiopharmaceuticals. This
field of radiochemistry is multidisciplinary, involving radiometal production, separation of the …

Bifunctional chelators in the design and application of radiopharmaceuticals for oncological diseases

D Sarko, M Eisenhut, U Haberkorn… - Current medicinal …, 2012 - ingentaconnect.com
Radiopharmaceuticals constitute diagnostic and therapeutic tools for both clinical and
preclinical applications. They are a blend of a tracer moiety that mediates a site specific …