[HTML][HTML] Coordinating gene expression during the cell cycle
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Widespread intronic polyadenylation inactivates tumour suppressor genes in leukaemia
DNA mutations are known cancer drivers. Here we investigated whether mRNA events that
are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA …
are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA …
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …
the RB pathway have been identified in almost every human malignancy. The E2F …
The E2F transcriptional network: old acquaintances with new faces
DK Dimova, NJ Dyson - Oncogene, 2005 - nature.com
Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …
retinoblastoma protein. E2F factors have been known for several years to be important …
Pocket proteins and cell cycle control
D Cobrinik - Oncogene, 2005 - nature.com
The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the 'pocket
protein'family of cell cycle regulators. These proteins are best known for their roles in …
protein'family of cell cycle regulators. These proteins are best known for their roles in …
Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis
J DeGregori, DG Johnson - Current molecular medicine, 2006 - ingentaconnect.com
Since the discovery almost fifteen years ago that E2F transcription factors are key targets of
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
Most heritable traits, including disease susceptibility, are affected by interactions between
multiple genes. However, we understand little about how genes interact because very few …
multiple genes. However, we understand little about how genes interact because very few …
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation
Z Nagy, L Tora - Oncogene, 2007 - nature.com
Transcription in eukaryotes is a tightly regulated, multistep process. Gene-specific
transcriptional activators, several different co-activators and general transcription factors are …
transcriptional activators, several different co-activators and general transcription factors are …
The MYST family of histone acetyltransferases and their intimate links to cancer
N Avvakumov, J Cote - Oncogene, 2007 - nature.com
The histone acetyltransferases (HATs) of the MYST family are highly conserved in
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …