Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

With a growing aged population, there is an imminent need to develop new therapeutic
strategies to ameliorate disorders of hematopoietic aging, including clonal hematopoiesis …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal
hematopoietic stem cell diseases arising from the bone marrow (BM), and approximately …

IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …

DDX41 mutations are the most common germline alterations in adult myelodysplastic
syndromes (MDSs). The majority of affected individuals harbor germline monoallelic …

Recent genome‐wide studies have revealed that aging or chronic inflammation can cause
clonal expansion of cells in normal tissues. Clonal hematopoiesis has been the most …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Lifelong blood production is maintained by bone marrow (BM)-residing hematopoietic stem
cells (HSCs) that are defined by two special properties: multipotency and self-renewal. Since …