Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

T Nojima, NJ Proudfoot - Nature reviews Molecular cell biology, 2022 - nature.com
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Exploring the expanding universe of small RNAs

J Shi, T Zhou, Q Chen - Nature cell biology, 2022 - nature.com
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Z Su, I Monshaugen, B Wilson, F Wang… - Nature …, 2022 - nature.com
RNA modifications are important regulatory elements of RNA functions. However, most
genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer …

Small RNA modifications: regulatory molecules and potential applications

Q Xiong, Y Zhang - Journal of Hematology & Oncology, 2023 - Springer
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …

Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs

Y Zhang, L Ren, X Sun, Z Zhang, J Liu, Y Xin… - Nature …, 2021 - nature.com
Paternal environmental inputs can influence various phenotypes in offspring, presenting
tremendous implications for basic biology and public health and policy. However, which …

tRNA therapeutics for genetic diseases

J Coller, Z Ignatova - Nature Reviews Drug Discovery, 2024 - nature.com
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

tRNA renovatio: rebirth through fragmentation

B Kuhle, Q Chen, P Schimmel - Molecular Cell, 2023 - cell.com
Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

[HTML][HTML] Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice

J Liu, J Shi, R Hernandez, X Li, P Konchadi… - Environment …, 2023 - Elsevier
Exposure to ubiquitous plastic-associated endocrine disrupting chemicals (EDCs) is
associated with the increased risk of many chronic diseases. For example, phthalate …