Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

[HTML][HTML] Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

Q Kang, C Yang - Redox biology, 2020 - Elsevier
Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

Antidiabetic properties of dietary flavonoids: a cellular mechanism review

R Vinayagam, B Xu - Nutrition & metabolism, 2015 - Springer
Background Natural food products have been used for combating human diseases for
thousands of years. Naturally occurring flavonoids including flavones, flavonols, flavanones …

[HTML][HTML] In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

GJ Shi, Y Li, QH Cao, HX Wu, XY Tang, XH Gao… - Biomedicine & …, 2019 - Elsevier
Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions,
including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly …

Quercetin: An effective polyphenol in alleviating diabetes and diabetic complications

L Yan, M Vaghari-Tabari, F Malakoti… - Critical reviews in …, 2023 - Taylor & Francis
Various studies, especially in recent years, have shown that quercetin has beneficial
therapeutic effects in various human diseases, including diabetes. Quercetin has significant …

Oxidative stress and microvascular alterations in diabetic retinopathy: future therapies

ML Rodríguez, S Pérez, S Mena-Mollá… - Oxidative Medicine …, 2019 - Wiley Online Library
Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …

Health benefits of polyphenols and carotenoids in age‐related eye diseases

S Bungau, MM Abdel-Daim, DM Tit… - Oxidative medicine …, 2019 - Wiley Online Library
Oxidative stress and inflammation play a critical role in the initiation and progression of age‐
related ocular abnormalities as cataract, glaucoma, diabetic retinopathy, and macular …

Polyphenols, food and pharma. Current knowledge and directions for future research

A Tresserra-Rimbau, RM Lamuela-Raventos… - Biochemical …, 2018 - Elsevier
Polyphenols are a large family of phytochemicals with great chemical diversity, known to be
bioactive compounds of foods, species, medicinal plants and nutraceuticals. These …

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets

S Nian, ACY Lo, Y Mi, K Ren, D Yang - Eye and Vision, 2021 - Springer
Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading
cause of visual loss in working-age individuals in many industrialized countries. It has been …

Quercetin inhibits the production of IL-1β-induced inflammatory cytokines and chemokines in ARPE-19 cells via the MAPK and NF-κB signaling pathways

SC Cheng, WC Huang, JH S. Pang, YH Wu… - International journal of …, 2019 - mdpi.com
Quercetin, a bioflavonoid derived from vegetables and fruits, exerts anti-inflammatory effects
in various diseases. Our previous study revealed that quercetin could suppress the …