[HTML][HTML] AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Z Dlamini, A Skepu, N Kim, M Mkhabele… - Informatics in Medicine …, 2022 - Elsevier
Precision medicine is the personalization of medicine to suit a specific group of people or
even an individual patient, based on genetic or molecular profiling. This can be done using …

Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway

W Xia, W Chen, C Ni, X Meng, J Wu, Q Yang… - Breast Cancer …, 2023 - Springer
Background Chemoresistance involves metastasis and aggressiveness of breast cancer
(BC). Chemotherapy-elicited exosomes have been reported to be associated with drug …

Asymmetrically split DNAzyme-based colorimetric and electrochemical dual-modal biosensor for detection of breast cancer exosomal surface proteins

W Cheng, Y Yao, D Li, C Duan, Z Wang… - Biosensors and …, 2023 - Elsevier
Exosomal surface proteins are potentially useful for breast cancer diagnosis and awareness
of risk. However, some detection techniques involving complex operations and expensive …

Proteomics-Based identification of dysregulated proteins and biomarker discovery in invasive ductal carcinoma, the most common breast cancer subtype

AN Neagu, D Whitham, L Seymour, N Haaker, I Pelkey… - Proteomes, 2023 - mdpi.com
Invasive ductal carcinoma (IDC) is the most common histological subtype of malignant
breast cancer (BC), and accounts for 70–80% of all invasive BCs. IDC demonstrates great …

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

AN Neagu, D Whitham, P Bruno, A Arshad… - International Journal of …, 2024 - mdpi.com
Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …

Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics

D Whitham, P Bruno, N Haaker, KF Arcaro… - Expert Review of …, 2024 - Taylor & Francis
Introduction Breast cancer is one of the most prevalent cancers among women in the United
States. Current research regarding breast milk has been focused on the composition and its …

Recent Contributions of Mass Spectrometry-Based “Omics” in the Studies of Breast Cancer

S Banerjee, M Hatimuria, K Sarkar, J Das… - Chemical Research …, 2023 - ACS Publications
Breast cancer (BC) is one of the most heterogeneous groups of cancer. As every biotype of
BC is unique and presents a particular “omic” signature, they are increasingly characterized …

Application of artificial intelligence in the diagnosis, treatment, and recurrence prediction of peritoneal carcinomatosis

GX Wei, YW Zhou, ZP Li, M Qiu - Heliyon, 2024 - cell.com
Peritoneal carcinomatosis (PC) is a type of secondary cancer which is not sensitive to
conventional intravenous chemotherapy. Treatment strategies for PC are usually palliative …

Generation and Characterization of Trastuzumab/Pertuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

M Sanz-Álvarez, M Luque, M Morales-Gallego… - International Journal of …, 2023 - mdpi.com
The combination of trastuzumab and pertuzumab as first-line therapy in patients with HER2-
positive breast cancer has shown significant clinical benefits compared to trastuzumab …