Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …

Occupational or environmental exposures to heavy metals produce several adverse health
effects. The common mechanism determining their toxicity and carcinogenicity is the …

In numerous experimental models, sulforaphane (SFN) is shown herein to induce hormetic
dose responses that are not only common but display endpoints of biomedical and clinical …

Sulforaphane, a naturally occurring compound found in cruciferous vegetables, has been
shown to be neuroprotective in several neurological disorders. In this study, we sought to …

Acute kidney injury (AKI) is a common clinical syndrome that is related to high morbidity and
mortality. Oxidative stress, including the production of reactive oxygen species (ROS) …

Redox is a constant phenomenon in organisms. From the signaling pathway transduction to
the oxidative stress during the inflammation and disease process, all are related to reduction …

Gentamicin-induced nephrotoxicity has been well documented, although its underlying
mechanisms and preventive strategies remain to be investigated. The present study was …

Oxidative stress and mitochondrial dysfunction are associated with the pathogenesis of
several human diseases. The excessive generation of reactive oxygen species (ROS) …