Macroautophagy/autophagy is vital for intracellular quality control and homeostasis.
Therefore, careful regulation of autophagy is very important. In the past 10 years, a number …

The ultimate goal of cancer biomarker discovery is to use individual patient-derived
biochemical information to improve patients' outcomes. A recent increase in the spectrum of …

Background Breast cancer (BC) is a heterogeneous disease characterised by variant
biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC …

Breast cancer (BC) is a heterogeneous disease characterised by variant biology, metabolic
activity and patient outcome. This study aimed to evaluate the biological and prognostic …

Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex
hormone that not only promotes the development of female secondary sexual …

Background Mitogen-activated protein kinases (MAPKs) are signalling transduction
molecules that have different functions and diverse behaviour in cancer. In breast cancer …

Background: Although distant metastasis (DM) in breast cancer (BC) is the most lethal form
of recurrence and the most common underlying cause of cancer related deaths, the outcome …

Objective: To investigate the effects of rapamycin (RAPA) on the tumor growth of lung cancer
in the mice bearing A549 and the mechanisms. Methods: 60 mice with A549 lung cancer …

Background Metabolic reprograming is now a recognized hallmark of cancer. The prostate‐
specific phosphatase and tensin homolog deleted on chromosome 10 (Pten) gene …

Cancer recurrence is the major cause of cancer mortality. Despite tremendous research
efforts, there is a dearth of biomarkers that reliably predict risk of cancer recurrence …