Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Nitric oxide is a signaling molecule produced by neurons and endothelial cells in the brain.
NO is synthesized from L-arginine and oxygen by nitric oxide synthase: neuronal (nNOS) …

The molecular pathogenesis of Alzheimer's disease (AD) involves the participation of the
amyloid-β-peptide (Aβ), which plays a critical role in the neurodegeneration that triggers the …

Cerebral amyloid angiopathy of the β‐amyloid type (Aβ‐CAA) is a risk factor for hemorrhagic
stroke and independently is believed to contribute to dementia. Naturally occurring animal …

Cerebral amyloid angiopathy (CAA) is the result of the deposition of an amyloidogenic
protein in cortical and leptomeningeal vessels. The most common type of CAA is caused by …

Neuropathological changes generated by human amyloid-β peptide (Aβ) fibrils and Aβ-
acetylcholinesterase (Aβ-AChE) complexes were compared in rat hippocampus in vivo …

Recent studies have suggested that testosterone levels are lower in men with Alzheimer's
disease and that testosterone treatment improves cognition in older men. Since testosterone …

The contributing effect of cerebrovascular pathology in Alzheimer's disease (AD) has
become increasingly appreciated. Recent evidence suggests that amyloid-β peptide (Aβ) …

Oxidative stress is a key mechanism in amyloid β-peptide (Aβ)-mediated neurotoxicity;
therefore, the protective roles of 17β-estradiol (E 2) and antioxidants (Trolox and vitamin C) …