Design and engineering of light-sensitive protein switches

AC McCue, B Kuhlman - Current opinion in structural biology, 2022 - Elsevier
Engineered, light-sensitive protein switches are used to interrogate a broad variety of
biological processes. These switches are typically constructed by genetically fusing naturally …

[HTML][HTML] BMP signaling: lighting up the way for embryonic dorsoventral patterning

Y Yan, Q Wang - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
One of the most significant events during early embryonic development is the establishment
of a basic embryonic body plan, which is defined by anteroposterior, dorsoventral (DV), and …

Precise modulation of embryonic development through optogenetics

H Fan, C Barnes, H Hwang, K Zhang, J Yang - genesis, 2022 - Wiley Online Library
The past decade has witnessed enormous progress in optogenetics, which uses photo‐
sensitive proteins to control signal transduction in live cells and animals. The ever …

[HTML][HTML] Opticool: Cutting-edge transgenic optical tools

KD Fenelon, J Krause, T Koromila - Plos Genetics, 2024 - journals.plos.org
Only a few short decades have passed since the sequencing of GFP, yet the modern
repertoire of transgenically encoded optical tools implies an exponential proliferation of ever …

Designing Chemical-and Light-Activated Protein Switches for Regulating Peptide Functions

J Shen - 2023 - deepblue.lib.umich.edu
Peptides serve important biological functions including neuromodulation, hormonal
regulation, cell signaling, protein localization, and enzyme inhibition. The ability to modulate …