Rodent models for Alzheimer disease
Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …
course of more than two decades, an increasing number of complementary rodent models …
Genomic interventions for sustainable agriculture
Agricultural production faces a Herculean challenge to feed the increasing global
population. Food production systems need to deliver more with finite land and water …
population. Food production systems need to deliver more with finite land and water …
[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …
correlated with health. Understanding the extent to which, and how, host genetics …
[HTML][HTML] Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements
Diverse inbred mouse strains are important biomedical research models, yet genome
characterization of many strains is fundamentally lacking in comparison with humans. In …
characterization of many strains is fundamentally lacking in comparison with humans. In …
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci
We report full-length draft de novo genome assemblies for 16 widely used inbred mouse
strains and find extensive strain-specific haplotype variation. We identify and characterize …
strains and find extensive strain-specific haplotype variation. We identify and characterize …
Meiosis: the chromosomal foundation of reproduction
E Bolcun-Filas, MA Handel - Biology of reproduction, 2018 - academic.oup.com
Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …
High-diversity mouse populations for complex traits
Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …
complex disease mechanisms. Advanced high-diversity mouse populations include the …
Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …
pathogen's ability to adapt to the variable immune pressures exerted by the host …
Leveraging preclinical models for the development of Alzheimer disease therapeutics
K Scearce-Levie, PE Sanchez… - Nature Reviews Drug …, 2020 - nature.com
A large number of mouse models have been engineered, characterized and used to
advance biomedical research in Alzheimer disease (AD). Early models simply damaged the …
advance biomedical research in Alzheimer disease (AD). Early models simply damaged the …
A conserved transcriptional program for MAIT cells across mammalian evolution
H Bugaut, Y El Morr, M Mestdagh, A Darbois… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs,
suggesting important functions. As human and mouse MAIT functional programs appear …
suggesting important functions. As human and mouse MAIT functional programs appear …