Group B streptococcus: virulence factors and pathogenic mechanism

Y Liu, J Liu - Microorganisms, 2022 - mdpi.com
Group B Streptococcus (GBS) or Streptococcus agalactiae is a major cause of neonatal
mortality. When colonizing the lower genital tract of pregnant women, GBS may cause …

Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation

AM Keestra-Gounder, PE Nagao - Frontiers in Immunology, 2023 - frontiersin.org
The inflammasomes are intracellular multimeric protein complexes consisting of an innate
immune sensor, the adapter protein ASC and the inflammatory caspases-1 and/or-11 and …

Formation and function of the meningeal arachnoid barrier around the developing mouse brain

J Derk, CN Como, HE Jones, LR Joyce, S Kim… - Developmental cell, 2023 - cell.com
The arachnoid barrier, a component of the blood-cerebrospinal fluid barrier (B-CSFB) in the
meninges, is composed of epithelial-like, tight-junction-expressing cells. Unlike other central …

Biomarker Identification for Preterm Birth Susceptibility: Vaginal Microbiome Meta‐Analysis Using Systems Biology and Machine Learning Approaches

S Kulshrestha, P Narad, B Singh, SS Pai… - American Journal of …, 2024 - Wiley Online Library
Problem The vaginal microbiome has a substantial role in the occurrence of preterm birth
(PTB), which contributes substantially to neonatal mortality worldwide. However, current …

[HTML][HTML] Inflammatory Mechanisms of Preterm Labor and Emerging Anti-Inflammatory Interventions

T Habelrih, TL Augustin, F Mauffette-Whyte… - Cytokine & Growth …, 2024 - Elsevier
Preterm birth is a major public health concern, requiring a deeper understanding of its
underlying inflammatory mechanisms and to develop effective therapeutic strategies. This …

An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive

KGK Goh, D Desai, R Thapa, D Prince… - FEMS Microbiology …, 2024 - academic.oup.com
Abstract Group B Streptococcus (GBS; also known as Streptococcus agalactiae) is an
opportunistic bacterial pathogen that causes sepsis, meningitis, pneumonia, and skin and …

Comparative Analysis of Microbial Species and Multidrug Resistance Patterns Associated with Lower Urinary Tract Infections in Preterm and Full-Term Births

F Bratosin, R Folescu, P Krupyshev, ZL Popa, C Citu… - Microorganisms, 2024 - mdpi.com
The rise of multidrug-resistant organisms has significantly complicated the clinical
management of urinary tract infections (UTIs), particularly in the context of pregnancy. This …

Molecular evidence that GBS early neonatal sepsis results from ascending infection: comparative hybrid genomics analyses show that microorganisms in the vaginal …

P Pongchaikul, R Romero, T Wongsurawat… - Journal of Perinatal …, 2024 - degruyter.com
Abstract Objectives Streptococcus agalactiae, or Group B Streptococcus (GBS), is a leading
cause of neonatal sepsis. Materno-fetal transmission of the microorganisms present in the …

Current research update on group B streptococcal infection related to obstetrics and gynecology

Y Liu, H Ai - Frontiers in Pharmacology, 2024 - frontiersin.org
Group B streptococcal (GBS) is a Gram-positive bacterium that is commonly found in the
gastrointestinal tract and urogenital tract. GBS infestation during pregnancy is a significant …

Identification of Glyoxalase A in Group B Streptococcus and its contribution to methylglyoxal tolerance and virulence

MS Akbari, LR Joyce, BL Spencer, A Brady, KS McIver… - bioRxiv, 2024 - biorxiv.org
Abstract Group B Streptococcus (GBS) is a Gram-positive pathobiont that commonly
colonizes the gastrointestinal and lower female genital tracts but can cause sepsis and …