The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
The physiological function of different voltage-gated sodium channels in pain
G Goodwin, SB McMahon - Nature Reviews Neuroscience, 2021 - nature.com
Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
[HTML][HTML] Selective Inhibition of NaV1.8 with VX-548 for Acute Pain
J Jones, DJ Correll, SM Lechner, I Jazic… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background The NaV1. 8 voltage-gated sodium channel, expressed in peripheral
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …
promising target for developing next-generation analgesics. A prominent characteristic of …
Gene variant effects across sodium channelopathies predict function and guide precision therapy
A Brunklaus, T Feng, T Brünger, E Perez-Palma… - Brain, 2022 - academic.oup.com
Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …
Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief
Introduction: Chronic pain is a massive clinical problem. We discuss the potential of subtype
selective sodium channel blockers that may provide analgesia with limited side effects …
selective sodium channel blockers that may provide analgesia with limited side effects …
Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy
Sodium channel Nav1. 9 is expressed in peripheral nociceptive neurons, as well as visceral
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …
afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy …
NaV1.9: a sodium channel linked to human pain
SD Dib-Hajj, JA Black, SG Waxman - Nature Reviews Neuroscience, 2015 - nature.com
The voltage-gated sodium channel NaV1. 9 is preferentially expressed in nociceptors and
has been shown in rodent models to have a major role in inflammatory and neuropathic …
has been shown in rodent models to have a major role in inflammatory and neuropathic …
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery
P Imbrici, A Liantonio, GM Camerino… - Frontiers in …, 2016 - frontiersin.org
In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …
Sodium channel genes in pain-related disorders: phenotype–genotype associations and recommendations for clinical use
SG Waxman, ISJ Merkies, MM Gerrits… - The Lancet …, 2014 - thelancet.com
Human studies have firmly implicated voltage-gated sodium channels in human pain
disorders, and targeted and massively parallel genomic sequencing is beginning to be used …
disorders, and targeted and massively parallel genomic sequencing is beginning to be used …