Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …

It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A
reaction, function as mediators through G-protein-coupled receptors. Notably, recent studies …

The cysteinyl leukotrienes (cys-LTs), leukotriene C 4 (LTC 4), a conjugation product of
glutathione and eicosatetraenoic acid, and its metabolites, LTD 4 and LTE 4, are lipid …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

The P2Y receptors are a widely expressed group of eight nucleotide-activated G protein-
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …

Once introduced into the very early eukaryotic blueprint, seven-transmembrane receptors
soon became the central and versatile components of the evolutionary highly successful G …

GPR34 is a Gi/o protein‐coupled receptor (GPCR) of the nucleotide receptor P2Y12‐like
group. This receptor is highly expressed in microglia, however, the functional relevance of …

The X-chromosomal GPR34 gene encodes an orphan G i protein-coupled receptor that is
highly conserved among vertebrates. To evaluate the physiological relevance of GPR34, we …

G protein–coupled receptors (GPCRs) are encoded by over 800 genes in the human
genome. Motivated by different scientific rationales, the two classification systems that are …

G protein-coupled receptors (GPCRs) play a crucial role as membrane receptors, facilitating
the communication of eukaryotic species with their environment and regulating cellular and …