Abstract Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein
involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved …

MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

MicroRNAs are short regulatory RNAs that are able to post-transcriptionally modulate gene
expression and that have crucial roles in the control of physiological and pathological …

Cancer is a multistep disease based on crucial interactions between tumor cells and the
microenvironment (extracellular matrix and stroma/immune cells). In fact, during …

Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic
agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we …

Skin cancer is, at present, the most common type of malignancy in the Caucasian
population. Its incidence has increased rapidly in the last decade for both melanoma and …

Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs)
and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent …

Pyroptosis is a type of proinflammatory programmed cell death mediated by caspase 1
activity and occurs in several types of eukaryotic tumor cells, including gliomas. MicroRNAs …

Abstract The Activator Protein 2 (AP-2) transcription factor (TF) family is vital for the
regulation of gene expression during early development as well as carcinogenesis process …

The long non‑coding RNA nuclear enrich abundant transcript 1 (NEAT1) has been identified
to be carcinogenic in various cancers and elevated NEAT1 expression was tightly linked to …