Involvement of extracellular matrix (ECM) components in aging and age-related
neurodegeneration is not well understood. The role of hyaluronan (HA), a major …

Interaction of a tumor with its microenvironment is an emerging field of investigation, and the
crosstalk between cancer cells and the extracellular matrix is of particular interest, since …

Abstract Background Perineuronal nets (PNNs) are insoluble aggregates of extracellular
matrix molecules in the brain that consist of hyaluronan (HA) and chondroitin sulfate …

Hyaluronan (HA) is a central component of the extracellular matrix (ECM) in the brain and
plays a pivotal role in neural development and plasticity. Brain HA exists in 2 distinct forms of …

Chondroitin sulfate (CS) and heparan sulfate (HS) are sulfated glycosaminoglycan (GAG)
chains that consist of repeating disaccharide units composed of hexosamine and hexuronic …

Parvalbumin-expressing (PV) interneurons fast inhibit excitatory neurons in various brain
areas. Perineuronal nets (PNNs), accumulating around PV neurons, have been shown to …

Residual mechanical stresses, also known as solid stresses, emerge during rapid
differential growth or remodeling of tissues, as observed in morphogenesis and tumor …

Radial neuronal migration is a key neurodevelopmental event for proper cortical laminar
organization. The multipolar-to-bipolar transition, a critical step in establishing neuronal …

Hyaluronan (HA) is a central component of the extracellular matrix (ECM) in the central
nervous system. Brain HA exists in two distinct forms of ECM: the diffuse ECM, which is …

The role of extracellular components in the aging phenotype is not well understood. A long
living rodent, the Naked Mole Rat (NMR), presents as a salient model of healthy aging …