Diabetes is a severe chronic disease worldwide. In various types of diabetes, the pancreatic
beta cells fail to secrete sufficient insulin, at some point, to regulate blood glucose levels …

Type 1 diabetes mellitus (T1DM) is a chronic condition primarily managed with insulin
replacement, leading to significant treatment costs. Complications include vasculopathy …

Adipose tissue-derived microvascular fragments (MVF) serve as vascularization units in
tissue engineering and regenerative medicine. Because a three-dimensional cellular …

In the context of diabetes mellitus, various pathological changes cause tissue ischemia and
hypoxia, which can lead to the compensatory formation of neovascularization. However …

Background and Purpose Pancreatic islet transplantation is a promising therapeutic
approach for Type 1 diabetes. A major prerequisite for the survival of grafted islets is a rapid …

Revascularization of transplanted pancreatic islets is critical for survival and treatment of
type 1 diabetes. Questions concerning how islets influence local microvascular networks …