Development and functions of the choroid plexus–cerebrospinal fluid system

MP Lun, ES Monuki, MK Lehtinen - Nature Reviews Neuroscience, 2015 - nature.com
The choroid plexus (ChP) is the principal source of cerebrospinal fluid (CSF), which has
accepted roles as a fluid cushion and a sink for nervous system waste in vertebrates …

Development of the cerebellum: simple steps to make a 'little brain'

T Butts, MJ Green, RJT Wingate - Development, 2014 - journals.biologists.com
The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly.
Increasing interest in the cerebellum as a participant in higher cognitive processes and as a …

Subtypes of medulloblastoma have distinct developmental origins

P Gibson, Y Tong, G Robinson, MC Thompson… - Nature, 2010 - nature.com
Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour
subtypes that together comprise the most common malignant childhood brain tumour …

Stalled developmental programs at the root of pediatric brain tumors

S Jessa, A Blanchet-Cohen, B Krug, M Vladoiu… - Nature …, 2019 - nature.com
Childhood brain tumors have suspected prenatal origins. To identify vulnerable
developmental states, we generated a single-cell transcriptome atlas of> 65,000 cells from …

The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy

MK Lehtinen, CS Bjornsson, SM Dymecki… - Journal of …, 2013 - Soc Neuroscience
Although universally recognized as the source of cerebrospinal fluid (CSF), the choroid
plexus (ChP) has been one of the most understudied tissues in neuroscience. The reasons …

Optimized Gal4 genetics for permanent gene expression mapping in zebrafish

M Distel, MF Wullimann… - Proceedings of the …, 2009 - National Acad Sciences
Combinatorial genetics for conditional transgene activation allows studying gene function
with temporal and tissue specific control like the Gal4-UAS system, which has enabled …

Development and developmental disorders of the human cerebellum

HJ ten Donkelaar, WFA den Dunnen… - … disorders of the human …, 2023 - Springer
The cerebellum is one of the best studied parts of the brain. The cerebellar cortex is
composed of four main types of neurons: granule cells, Purkinje cells, and two types of …

A developmental and genetic classification for midbrain-hindbrain malformations

AJ Barkovich, KJ Millen, WB Dobyns - Brain, 2009 - academic.oup.com
Advances in neuroimaging, developmental biology and molecular genetics have increased
the understanding of developmental disorders affecting the midbrain and hindbrain, both as …

The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond

MW Zappaterra, MK Lehtinen - Cellular and molecular life sciences, 2012 - Springer
The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu
that regulates brain development, homeostasis, and disease. Advances in proteomics …

[HTML][HTML] Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps

AF Farago, RB Awatramani, SM Dymecki - Neuron, 2006 - cell.com
The cochlear nuclear complex (CN) is the entry point for central auditory processing.
Although constituent neurons have been studied physiologically, their embryological origins …