Exosomes as a new frontier of cancer liquid biopsy

D Yu, Y Li, M Wang, J Gu, W Xu, H Cai, X Fang… - Molecular cancer, 2022 - Springer
Liquid biopsy, characterized by minimally invasive detection through biofluids such as
blood, saliva, and urine, has emerged as a revolutionary strategy for cancer diagnosis and …

[HTML][HTML] Regulation of exosome production and cargo sorting

H Wei, Q Chen, L Lin, C Sha, T Li, Y Liu… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Cellular communication can be mediated by the exchange of biological information, mainly
in the form of proteins and RNAs. This can occur when extracellular vesicles, such as …

Towards development of a novel universal medical diagnostic method: Raman spectroscopy and machine learning

NM Ralbovsky, IK Lednev - Chemical Society Reviews, 2020 - pubs.rsc.org
Many problems exist within the myriad of currently employed screening and diagnostic
methods. Further, an incredibly wide variety of procedures are used to identify an even …

Present and future of surface-enhanced Raman scattering

J Langer, D Jimenez de Aberasturi, J Aizpurua… - ACS …, 2019 - ACS Publications
The discovery of the enhancement of Raman scattering by molecules adsorbed on
nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical …

Highly sensitive and reproducible SERS substrates based on ordered micropyramid array and silver nanoparticles

C Zhang, S Chen, Z Jiang, Z Shi… - ACS applied materials …, 2021 - ACS Publications
The construction of a highly sensitive and reproducible surface-enhanced Raman scattering
(SERS) substrate is the key factor that restricts its practical application. In this paper, a three …

[HTML][HTML] Progress of exosomes in the diagnosis and treatment of lung cancer

K Xu, C Zhang, T Du, ANA Gabriel, X Wang, X Li… - Biomedicine & …, 2021 - Elsevier
The incidence and mortality of lung cancer account for first place all over the world. Lung
cancer lacks early diagnostic biomarkers; lung cancer patients are usually diagnosed in …

[HTML][HTML] Exosome detection via surface-enhanced Raman spectroscopy for cancer diagnosis

J Li, Y Li, P Li, Y Zhang, L Du, Y Wang, C Zhang… - Acta biomaterialia, 2022 - Elsevier
As nanoscale extracellular vesicles, exosomes are secreted by various cell types, and they
are widely distributed in multiple biological fluids. Studies have shown that tumor-derived …

Single particle automated Raman trapping analysis of breast cancer cell-derived extracellular vesicles as cancer biomarkers

J Penders, A Nagelkerke, EM Cunnane, SV Pedersen… - ACS …, 2021 - ACS Publications
Extracellular vesicles (EVs) secreted by cancer cells provide an important insight into cancer
biology and could be leveraged to enhance diagnostics and disease monitoring. This paper …

Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy

Y Liang, BM Lehrich, S Zheng… - Journal of Extracellular …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are released by many cell types and distributed within various
biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique …

Personalized detection of circling exosomal PD-L1 based on Fe3O4@ TiO2 isolation and SERS immunoassay

Y Pang, J Shi, X Yang, C Wang, Z Sun… - Biosensors and …, 2020 - Elsevier
Circling exosomal PD-L1 can be expected as a predictor for the clinical responds of anti-PD-
1/PD-L1 therapy. Here, we present a simple method integrating capture and analysis of …