BACKGROUND Within the antral follicle, the oocyte is reliant on metabolic support from its
surrounding somatic cells. Metabolism plays a critical role in oocyte developmental …

Lipid is the main energy storage and its metabolites act as important bioactive materials in
mammalian follicles. Triglycerides in cumulus-oocyte complexes (COCs) break down into …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …

Autophagy is a self-digestion process in cells that can maintain energy homeostasis under
normal circumstances. However, misfolded proteins, damaged mitochondria and other …

BACKGROUND While oocyte IVM is practiced sporadically it has not achieved widespread
clinical practice globally. However, recently there have been some seminal advances in our …

Oocytes are maintained in a state of meiotic arrest following the first meiotic division until
ovulation is triggered. Within the antral follicle, meiotic arrest is actively suppressed in a …

In vitro maturation (IVM) is an assisted reproduction technique with reduced hormone-
related side-effects. Several attempts to implement IVM in routine practice have failed …

Conventional heterologous mitochondrial replacement therapy is clinically complicated by
“tri-parental” ethical concerns and limited source of healthy donor oocytes or zygotes …

The purine molecular structure consists of fused pyrimidine and imidazole rings. Purines are
main pieces that conform the structure of nucleic acids which rule the inheritance processes …

Polycystic ovary syndrome (PCOS) is a complex heterogeneous disorder with reproductive
and metabolic consequences whose aetiology is still elusive. To understand the cellular …