Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease

LA Messenger, MA Miles, C Bern - Expert review of anti-infective …, 2015 - Taylor & Francis
Over the last 30 years, concomitant with successful transnational disease control programs
across Latin America, Chagas disease has expanded from a neglected, endemic parasitic …

[HTML][HTML] Acute Chagas disease: new global challenges for an old neglected disease

DV Andrade, KJ Gollob, WO Dutra - PLoS neglected tropical …, 2014 - journals.plos.org
Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although
over 100 years have passed since the discovery of Chagas disease, it still presents an …

Oral transmission of Chagas disease

MA Shikanai-Yasuda… - Clinical Infectious Diseases, 2012 - academic.oup.com
Chagas disease is now an active disease in the urban centers of countries of nonendemicity
and endemicity because of congenital and blood and/or organ transplantation transmissions …

Vector-borne parasitic zoonoses: emerging scenarios and new perspectives

DD Colwell, F Dantas-Torres, D Otranto - Veterinary parasitology, 2011 - Elsevier
Changing climate is not the only driver for alterations in the dynamic interaction between
arthropod vectors of zoonotic parasites and their hosts, including humans. A suite of other …

[HTML][HTML] Acute Chagas disease in Brazil from 2001 to 2018: a nationwide spatiotemporal analysis

EF Santos, ÂAO Silva, LM Leony… - PLoS neglected …, 2020 - journals.plos.org
Background In Brazil, acute Chagas disease (ACD) surveillance involves mandatory
notification, which allows for population-based epidemiological studies. We conducted a …

Risk of chronic cardiomyopathy among patients with the acute phase or indeterminate form of Chagas disease: a systematic review and meta-analysis

S Chadalawada, S Sillau, S Archuleta… - JAMA network …, 2020 - jamanetwork.com
Importance Chagas cardiomyopathy is associated with substantial morbidity and mortality.
Precise estimates of the risk of developing cardiomyopathy among patients with the acute or …

[HTML][HTML] Extracellular vesicles in trypanosomatids: host cell communication

AC Torrecilhas, RP Soares, S Schenkman… - Frontiers in Cellular …, 2020 - frontiersin.org
Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae:
Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis …

[HTML][HTML] Emerging and reemerging forms of Trypanosoma cruzi transmission

MA Shikanai Yasuda - Memórias do Instituto Oswaldo Cruz, 2022 - SciELO Brasil
This review aims to update and discuss the main challenges in controlling emergent and
reemergent forms of Trypanosoma cruzi transmission through organ transplantation, blood …

[HTML][HTML] Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead

KM Bonney, DM Engman - The American journal of pathology, 2015 - Elsevier
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of individuals infected with the protozoan parasite Trypanosoma cruzi. Since the …

Acute and congenital Chagas disease

C Bern, DL Martin, RH Gilman - Advances in parasitology, 2011 - Elsevier
The acute phase of Chagas disease lasts 4–8 weeks and is characterized by
microscopically detectable parasitaemia. Symptoms are usually mild with severe acute …