A paradigm shift in medicine: A comprehensive review of network-based approaches
Network medicine is a rapidly evolving new field of medical research, which combines
principles and approaches of systems biology and network science, holding the promise to …
principles and approaches of systems biology and network science, holding the promise to …
[HTML][HTML] Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery
In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …
interactome network to predict novel putative disease genes and modules. We first apply the …
The biological role of the collagen alpha-3 (VI) chain and its cleaved C5 domain fragment endotrophin in cancer
J Wang, W Pan - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract The collagen alpha-3 (VI) chain encoded by the gene COL6A3 is one of the 3
subunits of collagen VI which is a microfibrillar component of the extracellular matrix and is …
subunits of collagen VI which is a microfibrillar component of the extracellular matrix and is …
[HTML][HTML] CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment
Purpose Glioblastoma (GBM) patients suffer from a dismal prognosis, with standard of care
therapy inevitably leading to therapy-resistant recurrent tumors. The presence of cancer …
therapy inevitably leading to therapy-resistant recurrent tumors. The presence of cancer …
[HTML][HTML] Development and validation of a nomogram with an autophagy-related gene signature for predicting survival in patients with glioblastoma
Glioblastoma (GBM) is the most common brain tumor with significant morbidity and mortality.
Autophagy plays a vital role in GBM development and progression. We aimed to establish …
Autophagy plays a vital role in GBM development and progression. We aimed to establish …
Single‐cell RNA sequencing reveals cellular and molecular reprograming landscape of gliomas and lung cancer brain metastases
HF Sun, LD Li, IW Lao, X Li, BJ Xu… - Clinical and …, 2022 - Wiley Online Library
Background Brain malignancies encompass gliomas and brain metastases originating from
extracranial tumours including lung cancer. Approximately 50% of patients with lung …
extracranial tumours including lung cancer. Approximately 50% of patients with lung …
NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
C Marques, T Unterkircher, P Kroon, B Oldrini, A Izzo… - Elife, 2021 - elifesciences.org
The molecular basis underlying glioblastoma (GBM) heterogeneity and plasticity is not fully
understood. Using transcriptomic data of human patient-derived brain tumor stem cell lines …
understood. Using transcriptomic data of human patient-derived brain tumor stem cell lines …
[HTML][HTML] In silico drug repurposing in COVID-19: A network-based analysis
The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …
[HTML][HTML] Co-expression network analysis identifies molecular determinants of loneliness associated with neuropsychiatric and neurodegenerative diseases
JA Santiago, JP Quinn, JA Potashkin - International Journal of Molecular …, 2023 - mdpi.com
Loneliness and social isolation are detrimental to mental health and may lead to cognitive
impairment and neurodegeneration. Although several molecular signatures of loneliness …
impairment and neurodegeneration. Although several molecular signatures of loneliness …
[HTML][HTML] Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis
Circular RNAs (circRNAs) are a new acknowledged class of RNAs that has been shown to
play a major role in several biological functions both in physiological and pathological …
play a major role in several biological functions both in physiological and pathological …