Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

Chimeric antigen receptor (CAR) engineering of T cells has revolutionized the field of
cellular therapy for the treatment of cancer. Despite this success, autologous CAR-T cells …

T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic
agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the …

Background: Cancer is one of the leading causes of death worldwide. Over the years, a
number of conventional cytotoxic approaches for neoplastic diseases has been developed …

Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …

Natural killer (NK) cells are a critical component of the innate immune system. Chimeric
antigen receptors (CARs) re-direct NK cells toward tumor cells carrying corresponding …

Cancer has recently been identified as the leading cause of mortality worldwide. Several
conventional treatments and cytotoxic immunotherapies have been developed and made …

The past several years have seen tremendous advances in the engineering of immune
effector cells as therapy for cancer. While chimeric antigen receptors (CARs) have been …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …