The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer
development, ranging from proliferative signaling, evasion of growth-suppressor pathways …

For decades, cancer metastasis has been a heated topic for its high mortality. Previous
research has shown that pre-metastatic niche and metastatic niche are the 2 crucial steps in …

Simple Summary The high rate of cancers in both humans and in animals along with their
poor overall survival pose a major challenge in medicine. Therefore, a large amount of …

Tumor microenvironment, including extracellular matrix (ECM) and stromal cells, is a key
player during tumor development, from initiation, growth and progression to metastasis …

Objective: Gastric cancer is the most common malignant tumor of the digestive system. The
progression from gastritis to gastric cancer may be related to genetic factors, but the specific …

Breast cancer (BC) metastasis is an enormous challenge targeting BC therapy. The
extracellular matrix (ECM), the principal component of the BC metastasis niche, is the pivotal …

First identified in the 1980s, tenascin-C (TNC) is a multi-domain extracellular matrix
glycoprotein abundantly expressed during the development of multicellular organisms. TNC …

The treatment of metastatic breast cancer remained a challenge despite the recent
breakthrough in the immunotherapy regimens. Here, we addressed the multidimensional …

Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in
therapy, the treatment of hormone-dependent cancers remains an unmet health need. The …