[HTML][HTML] Acute kidney injury in the critically ill: an updated review on pathophysiology and management

P Pickkers, M Darmon, E Hoste, M Joannidis… - Intensive care …, 2021 - Springer
Acute kidney injury (AKI) is now recognized as a heterogeneous syndrome that not only
affects acute morbidity and mortality, but also a patient's long-term prognosis. In this …

Shiga Toxin–Producing Escherichia coli and the Hemolytic–Uremic Syndrome

SB Freedman, NCAJ van de Kar… - New England Journal of …, 2023 - Mass Medical Soc
Shiga Toxin–Producing Escherichia coli and the Hemolytic–Uremic Syndrome | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Typhaneoside-tetrahedral framework nucleic acids system: mitochondrial recovery and antioxidation for acute kidney injury treatment

R Yan, W Cui, W Ma, J Li, Z Liu, Y Lin - ACS nano, 2023 - ACS Publications
Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

A Werion, L Belkhir, M Perrot, G Schmit, S Aydin… - Kidney international, 2020 - Elsevier
Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and
the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed …

[HTML][HTML] Acute kidney injury prevalence, progression and long-term outcomes in critically ill patients with COVID-19: a cohort study

N Lumlertgul, L Pirondini, E Cooney, W Kok… - Annals of intensive …, 2021 - Springer
Background There are limited data on acute kidney injury (AKI) progression and long-term
outcomes in critically ill patients with coronavirus disease-19 (COVID-19). We aimed to …

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation

Z Deng, M He, H Hu, W Zhang, Y Zhang, Y Ge, T Ma… - Autophagy, 2024 - Taylor & Francis
ABSTRACT A growing number of studies have shown that melatonin is a potent agonist of
SIRT3 (sirtuin 3) and effectively protects mitochondria, suggesting melatonin as a promising …

[HTML][HTML] Acute kidney injury

JA Kellum, P Romagnani, G Ashuntantang… - Nature reviews Disease …, 2021 - nature.com
Acute kidney injury (AKI) is defined by a sudden loss of excretory kidney function. AKI is part
of a range of conditions summarized as acute kidney diseases and disorders (AKD), in …

Delivering optimal renal replacement therapy to critically ill patients with acute kidney injury

R Wald, W Beaubien-Souligny, R Chanchlani… - Intensive care …, 2022 - Springer
Critical illness is often complicated by acute kidney injury (AKI). In patients with severe AKI,
renal replacement therapy (RRT) is deployed to address metabolic dysfunction and volume …

dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury

C Baatarjav, T Komada, T Karasawa… - Cell Death & …, 2022 - nature.com
Rhabdomyolysis is a severe condition that commonly leads to acute kidney injury (AKI).
While double-stranded DNA (dsDNA) released from injured muscle can be involved in its …

[HTML][HTML] Emerging early diagnostic methods for acute kidney injury

Z Xiao, Q Huang, Y Yang, M Liu, Q Chen, J Huang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Many factors such as trauma and COVID-19 cause acute kidney injury (AKI). Late AKI have
a very high incidence and mortality rate. Early diagnosis of AKI provides a critical therapeutic …