The past decade has seen several critical advances in our understanding of hypothalamic–
pituitary–adrenal (HPA) axis regulation. Homeostatic physiological circuits need to integrate …

Stress is viewed as a state of real or perceived threat to homeostasis, the management of
which involves the endocrine, nervous, and immune systems. These systems work …

Objective: The objective is to formulate clinical practice guidelines for treating Cushing's
syndrome. Participants: Participants include an Endocrine Society-appointed Task Force of …

Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

Cushing's syndrome is a rare disorder resulting from prolonged exposure to excess
glucocorticoids. Early diagnosis and treatment of Cushing's syndrome is associated with a …

BackgroundCortisol plays a multifaceted role in major depression disorder (MDD). Diurnal
rhythms are disturbed, there is increased resistance to the feedback action of …

Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …

Cushing syndrome results from supraphysiological exposure to glucocorticoids and is
associated with significant morbidity and mortality. The pathogenesis includes …

Endogenous Cushing's syndrome (CS), a rare endocrine disorder characterized by cortisol
hypersecretion, is associated with psychiatric and neurocognitive disorders. Major …