Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing
family of natural products with diverse activities and structures. RiPP classes are defined by …

Microbial natural products constitute a wide variety of chemical compounds, many which can
have antibiotic, antiviral, or anticancer properties that make them interesting for clinical …

Cyclization of linear peptides is an effective strategy to convert flexible molecules into rigid
compounds, which is of great significance for enhancing the peptide stability and bioactivity …