Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …

Liver disease remains a leading cause of mortality worldwide despite recent successes in
the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling …

Fibrosis exists in almost all organs/tissues of the human body, plays an important role in the
occurrence and development of diseases and is also a hallmark of the aging process …

Thymosin beta 4 (Tβ4), an actin‐sequestering protein, is involved in tissue development and
regeneration. It prevents inflammation and fibrosis in several tissues. We investigated the …

Background Upon liver injury, quiescent hepatic stellate cells (qHSCs), reside in the
perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells (MFBs) …

Background and purpose Liver fibrosis constitutes a pathologic condition resulting in a
series of advanced liver diseases. Oleanane-type saponins are distinctive active …

Colorectal cancer (CRC) has high morbidity and mortality. Epithelial-mesenchymal transition
(EMT) is associated with CRC progression and metastasis. Glutaminolysis is essential for …

Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent
hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated …

As an intercellular signaling molecule, Hedgehog (Hh) plays a critical role in liver
fibrosis/regeneration. Transcription effectors Gli1 and Gli2 are key components of the Hh …

Background In the central nervous system (CNS) myelin sheaths stabilize, protect, and
electrically insulate axons. However, in demyelinating autoimmune CNS diseases such as …