Mitochondria, so much more than just being energy factories, also have the capacity to
synthesize macromolecules including phospholipids, particularly cardiolipin (CL) and …

Mitochondria are surrounded by the two membranes, the outer and inner membranes,
whose lipid compositions are optimized for proper functions and structural organizations of …

Studies of rare human genetic disorders of mitochondrial phospholipid metabolism have
highlighted the crucial role that membrane phospholipids play in mitochondrial …

Phospholipids are major components of biological membranes and play structural and
regulatory roles in various biological processes. To determine the biological significance of …

The hexameric HOPS (homotypic fusion and protein sorting) complex is a conserved
tethering complex at the lysosome-like vacuole, where it mediates tethering and promotes …

One of the major constituents of mitochondrial membranes is the phospholipids, which play
a key role in maintaining the structure and the functions of the mitochondria. However …

Mitochondria depend on the import of phospholipid precursors for the biosynthesis of
phosphatidylethanolamine (PE) and cardiolipin, yet the mechanism of their transport …

The pathogenic fungus Cryptococcus neoformans must overcome iron limitation to cause
disease in mammalian hosts. Previously, we reported a screen for insertion mutants with …

Objective Mitochondrial “retrograde” signaling may stimulate organelle biogenesis as a
compensatory adaptation to aberrant activity of the oxidative phosphorylation (OXPHOS) …

Abstract Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer's
disease (LOAD). Being a lysosomal 5'-3'exonuclease, its neuronal substrates remained …