Understanding the role of protein glycation in the amyloid aggregation process

I Sirangelo, C Iannuzzi - International Journal of Molecular Sciences, 2021 - mdpi.com
Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

The effect of cold atmospheric plasma on diabetes-induced enzyme glycation, oxidative stress, and inflammation; in vitro and in vivo

A Rezaeinezhad, P Eslami, H Mirmiranpour… - Scientific reports, 2019 - nature.com
Cold atmospheric plasma (CAP) is known as the versatile tool in different biological, and
medical applications. In this study, we investigated the effect of cold plasma on diabetes via …

Fructose and methylglyoxal-induced glycation alters structural and functional properties of salivary proteins, albumin and lysozyme

MY Muraoka, AB Justino, DC Caixeta, JS Queiroz… - PLoS …, 2022 - journals.plos.org
Glycation process refers to reactions between reduction sugars and amino acids that can
lead to formation of advanced glycation end products (AGEs) which are related to changes …

An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition

AB Uceda, L Mariño, R Casasnovas, M Adrover - Biophysical Reviews, 2024 - Springer
The formation of a heterogeneous set of advanced glycation end products (AGEs) is the final
outcome of a non-enzymatic process that occurs in vivo on long-life biomolecules. This …

[HTML][HTML] Glycine therapy inhibits the progression of cataract in streptozotocin-induced diabetic rats

F Bahmani, SZ Bathaie, SJ Aldavood… - Molecular vision, 2012 - ncbi.nlm.nih.gov
Purpose The purpose of this paper was to investigate the effect of the oral administration of L-
glycine (Gly) on the development of diabetic cataract induced by streptozotocin (STZ) in rats …

Mechanistic insights in glycation-induced protein aggregation

M Adrover, L Mariño, P Sanchis, K Pauwels… - …, 2014 - ACS Publications
Protein glycation causes loss-of-function through a process that has been associated with
several diabetic-related diseases. Additionally, glycation has been hypothesized as a …

Prolonged glycation of hen egg white lysozyme generates non amyloidal structures

S Ghosh, NK Pandey, A Singha Roy, DR Tripathy… - PloS one, 2013 - journals.plos.org
Glycation causes severe damage to protein structure that could lead to amyloid formation in
special cases. Here in this report, we have shown for the first time that hen egg white …

Lysozyme is a component of the innate immune system linked to obesity associated-chronic low-grade inflammation and altered glucose tolerance

JM Moreno-Navarrete, J Latorre, A Lluch, FJ Ortega… - Clinical Nutrition, 2021 - Elsevier
Background & aims Several proteins of the innate immune system are known to be
deregulated with insulin resistance. We here aimed to investigate the relationship among …

L-lysine supplementation improved glycemic control, decreased protein glycation, and insulin resistance in type 2 diabetic patients

H Mirmiranpour, SZ Bathaie, S Khaghani… - International Journal of …, 2021 - Springer
Background Lysine treatment decreased diabetic complications associated with type 2
diabetes in the rat models of diabetes and in vitro. Aims/hypothesis Herein, in a single …

Prevention of α-crystallin glycation and aggregation using l-lysine results in the inhibition of in vitro catalase heat-induced-aggregation and suppression of cataract …

F Bahmani, SZ Bathaie, SJ Aldavood… - International journal of …, 2019 - Elsevier
The principle role of α-crystallin is chaperoning activity that protect s other proteins against
different stresses. High glucose concentration induces the osmotic stress and results in …