Eukaryotic cell size control and its relation to biosynthesis and senescence
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition
How animals evolved from a single-celled ancestor, transitioning from a unicellular lifestyle
to a coordinated multicellular entity, remains a fascinating question. Key events in this …
to a coordinated multicellular entity, remains a fascinating question. Key events in this …
Systematic evaluation of horizontal gene transfer between eukaryotes and viruses
Gene exchange between viruses and their hosts acts as a key facilitator of horizontal gene
transfer and is hypothesized to be a major driver of evolutionary change. Our understanding …
transfer and is hypothesized to be a major driver of evolutionary change. Our understanding …
Cyclin D-Cdk4, 6 drives cell-cycle progression via the retinoblastoma protein's C-terminal helix
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive
cell proliferation. A well-known target of cyclin D-Cdk4, 6 is the retinoblastoma protein Rb …
cell proliferation. A well-known target of cyclin D-Cdk4, 6 is the retinoblastoma protein Rb …
Diploid-dominant life cycles characterize the early evolution of Fungi
KR Amses, DR Simmons… - Proceedings of the …, 2022 - National Acad Sciences
Most of the described species in kingdom Fungi are contained in two phyla, the Ascomycota
and the Basidiomycota (subkingdom Dikarya). As a result, our understanding of the biology …
and the Basidiomycota (subkingdom Dikarya). As a result, our understanding of the biology …
Genomes of fungi and relatives reveal delayed loss of ancestral gene families and evolution of key fungal traits
Fungi are ecologically important heterotrophs that have radiated into most niches on Earth
and fulfil key ecological services. Despite intense interest in their origins, major genomic …
and fulfil key ecological services. Despite intense interest in their origins, major genomic …
Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
Cell size is fundamental to cell physiology. For example, cell size determines the spatial
scale of organelles and intracellular transport and thereby affects biosynthesis. Although …
scale of organelles and intracellular transport and thereby affects biosynthesis. Although …
Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts
Cell-cycle checkpoints and DNA repair processes protect organisms from potentially lethal
mutational damage. Compared to other budding yeasts in the subphylum …
mutational damage. Compared to other budding yeasts in the subphylum …
Quiescence in Saccharomyces cerevisiae
LL Breeden, T Tsukiyama - Annual Review of Genetics, 2022 - annualreviews.org
Most cells live in environments that are permissive for proliferation only a small fraction of
the time. Entering quiescence enables cells to survive long periods of nondivision and …
the time. Entering quiescence enables cells to survive long periods of nondivision and …
On the molecular mechanisms regulating animal cell size homeostasis
E Zatulovskiy, JM Skotheim - Trends in Genetics, 2020 - cell.com
Cell size is fundamental to cell physiology because it sets the scale of intracellular geometry,
organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled …
organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled …