Abstract p53 functions as a transcription factor involved in cell-cycle control, DNA repair,
apoptosis and cellular stress responses. However, besides inducing cell growth arrest and …

The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

DNA replication in cancer cells is accompanied by stalling and collapse of the replication
fork and signalling in response to DNA damage and/or premature mitosis; these processes …

BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …

We have used an affinity purification method to identify substrates of protein kinase B/Akt.
One protein that associates with 14-3-3 in an Akt-dependent manner is shown here to be the …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

The tumour-suppressor gene p53 is frequently mutated in human cancers and is important
in the cellular response to DNA damage,. Although the p53 family members p63 and p73 …