[HTML][HTML] Gliding motility powers invasion and egress in Apicomplexa

K Frénal, JF Dubremetz, M Lebrun… - Nature Reviews …, 2017 - nature.com
Protozoan parasites have developed elaborate motility systems that facilitate infection and
dissemination. For example, amoebae use actin-rich membrane extensions called …

Toxoplasma Effectors Targeting Host Signaling and Transcription

MA Hakimi, P Olias, LD Sibley - Clinical microbiology reviews, 2017 - Am Soc Microbiol
Early electron microscopy studies revealed the elaborate cellular features that define the
unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) …

Origin and arrangement of actin filaments for gliding motility in apicomplexan parasites revealed by cryo-electron tomography

M Martinez, SK Mageswaran, A Guérin… - Nature …, 2023 - nature.com
The phylum Apicomplexa comprises important eukaryotic parasites that invade host tissues
and cells using a unique mechanism of gliding motility. Gliding is powered by actomyosin …

The molecular basis of erythrocyte invasion by malaria parasites

AF Cowman, CJ Tonkin, WH Tham, MT Duraisingh - Cell host & microbe, 2017 - cell.com
Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii

KM Brown, S Long, LD Sibley - MBio, 2017 - Am Soc Microbiol
Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species

L Koreny, M Zeeshan, K Barylyuk, EC Tromer… - PLoS …, 2021 - journals.plos.org
The apical complex is the instrument of invasion used by apicomplexan parasites, and the
conoid is a conspicuous feature of this apparatus found throughout this phylum. The conoid …

How apicomplexa parasites secrete and build their invasion machinery

MM Cova, MH Lamarque… - Annual Review of …, 2022 - annualreviews.org
Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

[HTML][HTML] Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa

N Dos Santos Pacheco, L Brusini, R Haase… - Nature …, 2022 - nature.com
Members of Apicomplexa are defined by apical cytoskeletal structures and secretory
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …

Biogenesis and discharge of the rhoptries: Key organelles for entry and hijack of host cells by the Apicomplexa

R Ben Chaabene, G Lentini… - Molecular …, 2021 - Wiley Online Library
Rhoptries are specialized secretory organelles found in the Apicomplexa phylum, playing a
central role in the establishment of parasitism. The rhoptry content includes membranous as …

Life cycle stages, specific organelles and invasion mechanisms of Eimeria species

A Burrell, FM Tomley, S Vaughan… - Parasitology, 2020 - cambridge.org
Apicomplexans, including species of Eimeria, pose a real threat to the health and wellbeing
of animals and humans. Eimeria parasites do not infect humans but cause an important …