The vast majority of cerebral stroke cases are caused by transient or permanent occlusion of
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …

Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and
metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic …

Cerebral ischemia is caused by perturbations in blood flow to the brain that trigger
sequential and complex metabolic and cellular pathologies. This leads to brain tissue …

Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Background In ischemic stroke, the function of the cerebral vasculature is impaired. This
vascular structure is formed by the so-called neurovascular unit (NVU). A better …

The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which
regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of …

Ischemic stroke is one of the leading causes of death, and even timely treatment can result
in severe disabilities. Reperfusion of the ischemic stroke region and restoration of the blood …

The search of effective anti-stroke neuroprotectors requires various stroke models adequate
for different aspects of the ischemic processes. The photothrombotic stroke model is …

Metastasis is the main cause of death in patients with cancer. The molecular mechanisms
underlying the different metastasis steps are not yet fully known, partly because most studies …

Aging reduces homeostasis and contributes to increasing the risk of brain diseases and
death. Some of the principal characteristics are chronic and low-grade inflammation, a …