Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Tumor microenvironment (TME) consists of a dynamic network of non-tumoral stromal cells,
including cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages …

Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or
epigenetic changes, and is the biggest challenge around the world. Cytokines, including …

Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …

Simple Summary This review focuses on eradicating cancer by targeting a surface protein
expressed on the endothelium—E-selectin—with a novel drug, uproleselan (GMI-1271) …

Chemokines and their cognate receptors comprise an intricate signaling network that
becomes high-jacked by cancer cells for uncontrollable tumor growth and dissemination …

The chemokine system, comprising 48 chemokines and 23 receptors, is critically involved in
several hallmarks of cancer. Yet, despite extensive efforts from the pharmaceutical sector …

Despite considerable advances in the evolution of anticancer therapies, metastasis still
remains the main cause of cancer mortality. Therefore, current strategies for cancer cure …

Cancer is the second leading cause of mortality worldwide. Skin cancer is the most common
cancer in South Africa with nearly 20,000 reported cases every year and 700 deaths. If …

The interaction between leukemia cells and the bone microenvironment is known to provide
drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug …