Background Despite the growing productivity of aquaculture, economic losses due to
infectious diseases, environmental pollution, and human safety concerns related to antibiotic …

抗菌肽是一类广泛存在于自然界生物体内的小分子多肽物质, 为机体固有免疫系统的重要组成
部分, 对革兰氏阴性菌, 革兰氏阳性菌, 真菌, 病毒和寄生虫等均具有较好的抑制或杀伤作用 …

The protozoan parasite Cryptocaryon irritans causes marine white spot disease in a wide
range of fish hosts, including gilthead seabream, a very sensitive species with great …

Cell-mediated cytotoxicity is a complex immune mechanism that involves the release of
several killing molecules, being perforin (PRF) one of the most important effector players …

NK-lysin, a homologue of granulysin among human, is predominantly found in natural killer
cells and cytotoxic T-lymphocytes, which plays a pivotal part in innate immune responses …

Antimicrobial peptides (AMPs) are a potent arm of the innate immune system that can
directly kill pathogens and induce immunomodulation. In the marine aquaculture, European …

The NK-lysin antimicrobial peptide, first identified in mammals, possesses both antibacterial
and cytotoxic activity against cancer cell lines. Homologue peptides isolated from different …

Antimicrobial peptides (AMP) comprise a wide range of small molecules with direct
antibacterial activity and immunostimulatory role and are proposed as promising substitutes …

NK-lysins are one of the most abundant antimicrobial peptides produced by cytotoxic T
lymphocytes (CTLs) and natural killer cells (NKs), and identified as a new class of …

Sexual dimorphism in immunity has been extensively documented across vertebrates, with
marked contrasts observed in immune responses between males and females. These …